Thread #220807905
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Fender Jaguar edish
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wtf lol
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nth for the holodem
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>>220808127
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sexo
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>>220808137
well now i want to try one too
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>>220808096
baka field of viewlets
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>>220808194
>>220808213
Hadrian’s wall. That guy fucked 13 year old boys.
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need ace combat 8
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East Asian girls….
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Erm..Leftypol?
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>>220808578
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forgot what i wanted to post
this wasn't it btw
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>>220808578
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>>220808578
such ugly disgusting art
before he became a drugmong my old friend would draw just like this
made me seethe because he could draw true to life shit too like it was nothing
but he preferred drugs and retard drugmong cartoon art
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>we need you to come in saturday and do someone else's job because we refuse to hire new people
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>>220808731
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>>220808731
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rorke on his way to decimate the shitter after a heavy night on the fosters and a kebab from El Halalmein
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>>220808731
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>>220808837
for me, it's the brotherhood of nod
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>>220808837
Edward the Confessor, my kang
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>>220808959
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>>220808971
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dangerous concept
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37y.o
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Mousenonce will spend all night shitting up the thread, taking peoples replies to zoophilia (which is illegal) because he needs the attention because he is a parasite and won't go back to britfeel (he doesn't get attention there) reminder to do what you must to stop him destroying the thread
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need lovely vesper to tuck me into bed
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>>220809139
obviously
>>220809142
are you a girl??
>>220809147
probably not, but you live in ice... sooooo oooooooooooooooooooooooooooooooooooooooo
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>>220809142
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>>220809081
without anti-dogfucking laws people would break after just one or two "but would you though" at a dog that is their preferred (dog) gender, just so you know. with how people all go "okay fine" after that with people they wouldnt
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I WAS NOT TOLD
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>>220809193
actually the most straightest and probably most non-jew song there is ever
normies probably put it on and go "ahahaha fruityyy" because its not because thats because they are ruining everything or are wrong about everything. half of the time when its put on as a joke its actually just really hetero
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>>220809181
pure coincidence, sir keir had every reason to trust and promote the "prince of darkness" and all of his proteges, there was no indication of the possibility for any israeli influence let alone sexual impropriety
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>>220809247
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chune (real)
>https://youtu.be/5qZo1wn4Du8?si=vxVWXwmTRiCCuzlB
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>>220809397
youre my soulmate and if you ever tried to break up with me in real life I would propose and you would say yes and you would never get out of the marriage (not gay religion but I would never let you go)
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>>220809397
if I knew you in real life I wouldve proposed to you and honestly what do you do in response to that? I mean when it started even slightly going downhill by the way, I would lock you down. I love you by the way
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>>220808753
corrrr bunny won
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>>220809434
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>>220809448
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>>220809458
good post. shame that you are funny (when you want to be). I know you are just teasing me though. I know you wanted me to say all that. I knew you felt something too...baka (by the way you should just propose to me)
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>>220809474
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imagine being a dog at home waiting for someone. imagine dragons
imagine a hyperbolic chamber of poppers and being staved to have 0% muscle mass (so that you cant even stand up). imagine dragons, imagine john lennno
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>>220809520
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>>220809514
vodka would probably propose to her bf desu. probably in a really cringe way and also probably on or about her motorbike
>>220809543
good. dick
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google patents dog food medication +"muscle relaxer" - Google Search
google.com
google patents dog food medication - Google Search
google.com
US5200218A - Composition for dog food - Google Patents
patents.google.com
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I am quite fond of mcdonalds Dr pepper
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an alkaloid (e.g., from a mushroom, kratom, kava, kanna, or combinations thereof), psilocin (3-[2 (dimethylamino)ethyl]-4-indolol), psilocybin ([3-(2- dimcthylaminocthyl)- 1 /7-indol-4-yl] dihydrogen phosphate), baeocystin, norbaeocystin, bufotenin, aeruginascin, mitaphylline, 7-OH-mitragynine, paynantheine, speciogynine, mitragynine, mitrajavine, ajmalicine, raubasine, akuammigine, ciliaphylline, corynantheidine, corynoxeine, corynoxine A and/or B, epicatechin, 7-hydroxymitragynine, isomitraphylline, isomitrafoline, isopteropodine, isorhynchophylline, isospeciofoline, mitraciliatine, mitragynine, an indole alkaloid, mitragynine oxindole B, mitrafoline, mitraphylline, oxindole alkaloid, mitraversine, paynantheine, rhynchophylline, speciociliatine, speciofoline, speciogynine, speciophylline, stipulatine, tetrahydroalstonine, joubertiamine dehydrojoubertiamine, dihydrojoubertiamine, joubertinamine, O- methyldehydrojoubertiamine, O-methyljouberiamine, O-methyldihydrojoubertiamine, 3’- methoxy-4’-o-methyl joubertiamine, 4-(3,4-dimehoxyphenyl)-4-[2- acetylmethylamino)ethyl]cyclohexanone, 4-(3-methoxy-4-hydroxy-phenyl)-4-[2 -
(aceylmethylamino)ethyl]cyclohexadienone, sceletium alkaloid A4, touruosamine, N- formyltortuosamine, N-acetyltortuosamine, a 3a-aryl-cis-octahydroindole class compound (e.g. mesembrine), C-seco mesembrine alkaloids (e.g. joubertiamine), an alkaloid containing a 2,3-disubstituted pyridine moiety and 2 nitrogen atoms (e.g. sceletium A4), a ring C-seco Sceletium alkaloid A4 group (e.g. tortuos amine), kavalactone (e.g., dihydrokavain, kavain, desmehtoxyyangonin, dihydromethysticin, yangonin, methysticin, of combinations of any of the foregoing (e.g., a combination of 2, 3, 4, 5, 6, or more of the foregoing). In some embodiments, the therapeutic ingredient further comprises one or more additional therapeutic agents.
[0016] Some embodiments pertain to
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>>220809592
giz a sip
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isomitraphylline (e.g., an immuno stimulant, anti-leukemic), isomitrafoline, isopteropodine (e.g., an immuno stimulant), isorhynchophylline (e.g., an immuno stimulant), isospeciofoline, mitraciliatine, mitragynine (e.g., analgesic, antitussive, antidiarrheal, adrenergic, antimalarial, possible psychedelic (5- HT2A) antagonist),
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mitragynine oxindole B, mitrafoline, mitraphylline (e.g., a vasodilator, antihypertensive, muscle relaxer, diuretic, antiamnesic, anti-leukemic, possible immunostimulant), oxindole alkaloid, mitraversine, paynantheine (e.g., a smooth muscle relaxer),
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the wet weight % of the one or more therapeutic agents present in the composition (with water included) is equal to or at least about: 0.1%, 0.5%, 0.75%, 1%, 1.5%, 2%, 3%, 4%, 5%, 7.5%, 10%, 15%, 20%, 25%, or ranges including and/or spanning the aforementioned values. In some embodiments
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Sceletium extracts, including individual compounds (e.g., therapeutic compounds) from Sceletium, isolates from Sceletium, distillates from Sceletium, broad spectrum extracts from Sceletium, and/or full spectrum extracts from Sceletium. In several embodiments, the therapeutic ingredient is a Sceletium extract. In several embodiments, the therapeutic ingredient is an active agent or a combination of active agents from Sceletium or a Sceletium extract. Sceletium is a succulent plant commonly found in South Africa, which is also known as Kanna, Channa, Kougoed. In some embodiments, the lipid particles are composed of and/or comprise Sceletium powders, Sceletium oils, and/or Sceletium active ingredients. In several embodiments, the therapeutic ingredient comprises, consists of, or consists essentially of a Sceletium extract. In several embodiments, the therapeutic ingredient is an active agent or a combination of active agents from a Sceletium extract. In several embodiments, the Sceletium extracts are from one or more Sceletium species. In several embodiments, the one or more species are selected from the Tortuosum family (Sceletium tortuosum; Sceletium crassicaule; Sceletium strictum; Sceletium expansum, Sceletium varians, etc.) or the Emarcidum family (Sceletium emarcidum; Sceletium exalatum, Sceletium rigidum, etc). In several embodiments, combinations of Sceletium species are used, other Sceletium species, or combinations of any of the foregoing.
[0122] In some embodiments, as disclosed elsewhere herein, the lipid particles are composed of and/or comprise Sceletium extracts (e.g., one or more Sceletium extracts). In some embodiments, the lipid particles are composed of and/or comprise Sceletium powders and/or Sceletium active ingredients (e.g., including but not limited to alkaloids). In several embodiments, the Sceletium extract is an alkaloid.
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In several embodiments, the Sceletium extract is selected from the group consisting of joubertiamine dehydrojoubertiamine dihydrojoubertiamine joubertinamine, O-methyldehydrojoubertiamine, O-methyljouberiamine, O-methyldihydrojoubertiamine, 3’-methoxy-4’-o-methyl joubertiamine, 4-(3,4-dimehoxyphenyl)-4-[2-acetylmethylamino)ethyl]cyclohexanone, 4-(3- methoxy-4-hydroxy-phenyl)-4-[2-(ace ylmethylamino)ethyl]cyclohexadienon e, sceletium alkaloid A4, touruosamine, N-formyltortuosamine, N-acetyltortuosamine, or combinations of any of the foregoing. In several embodiments, the Sceletium extract is a 3a-aryl-cis- octahydroindole class (e.g. mesembrine), C-seco mesembrine alkaloids (e.g. joubertiamine), an alkaloid containing a 2,3-disubstituted pyridine moiety and 2 nitrogen atoms (e.g. sceletium A4), a ring C-seco Sceletium alkaloid A4 group (e.g. tortuosamine), or combinations of the foregoing. In several embodiments, Sceletium extracts are extracted from Sceletium (e.g., are natural extracts). In other embodiments, Sceletium extracts may be produced synthetically (e.g., in a laboratory). In several embodiments asdasdhehe123456789
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Example 50: Preparation of Sceletium Extract Lipid Nanoparticles
[0429] Based on the inventor’s experience, the following prophetic examples are projected using controlled design of experiments.
[0430] A composition for the delivery of Sceletium (kanna) extract was prepared using the following method. The extract is expected to be composed of alkaloids, such as, but not limited to, joubertiamine dehydrojoubertiamine dihydrojoubertiamine joubertinamine, O-methyldehydrojoubertiamine, O- methyljouberiamine, O- methyldihydrojoubertiamine, 3’-methoxy-4’-o-methyl joubertiamine, 4-(3,4- dimehoxyphenyl)-4-[2-acetylmethylamino)ethyl]cyclohexanone, 4-(3-methoxy-4- hydroxy - phenyl)-4-[2-(aceylmethylamino)ethy l]cyclohexadienone, sceletium alkaloid A4, touruosamine, N-formyltortuosamine, N-acetyltortuosamine . To a minimal amount of ethanol, Sceletium extract is added along with medium chain triglycerides, Vegapure 867 GN, phosphatidylcholine, and Vitamin E. When all ingredients were dissolved, the solvent was removed to form a dried composition.
[0431] The aqueous phase was formed by dissolving citric acid, potassium sorbate, sodium benzoate, and Monk Fruit extract into grams of warm water. The aqueous phase was added to the dried lipid composition with mixing to form an oil-in-water emulsion. The particle size was reduced to 20 - 500 nm by high pressure homogenization.
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2.4. Preparation
Traditionally, Mesembryanthemum tortuosum is harvested by local people from October through to January. The above ground plant material is collected, crushed with a large stone on a flat rock and the pulp is put into a plastic bag (In former times sheepskin bags were used). The plastic bag is tied to exclude air, and the material is allowed to macerate in the hot sun for eight days with intermittent mixing. It is then spread out on a flat rock to dry in the sun, resulting in the traditional fermented kanna, which is light brown fibrous clumps [25]. In some cases, the fresh foliage or whole plant is simply crushed and placed in the sun to dry, or the fresh plant material is baked in the hot sand under fire [1]. Alternative and more production-oriented local methods include shade-drying the plants or using drying racks.
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After a low dose application of mesembrine, mainly the O- and N-demethyl-dihydro, hydroxy, and bis-demethyl-dihydro metabolites, and in case of mesembrenone only the N-demethyl and the N-demethyl-dihydro metabolite, could be detected in rat urine.
The O-demethylation of mesembrine was catalysed by CYP1A2, CYP2B6, CYP2C19, and CYP2D6, and the N-demethylation by CYP1A2, CYP2B6, CYP2C19, CYP2D6, CYP3A4, and CYP3A5. The O-demethylation of mesembrenone was catalysed by CYP2C9, CYP2C19, and CYP2D6, and the N-demethylation by CYP2C19, CYP2D6, and CYP3A4 [50]. The clinical significance of this metabolism is not yet known.
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The sea alga Martensia fragilis produces a potent inhibitor of lipid peroxidation. The active metabolite has been identified as martefragin A 110 and its first synthesis has been reported starting with R-citronellol[hair space]36111, (Scheme 1). Removal of the hydroxy group was followed by oxidative cleavage of the double bond to produce carboxylic acid 112 which was condensed (via its acid chloride) with oxazolidine 113 to give 114. Asymmetric azidation using the Evans procedure gave azide 115 in diastereomerically pure form.
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still don't understand how this works
it doesn't make sense
how is it possible
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>>220809776
https://pubs.rsc.org/en/content/articlelanding/2002/g9/c8np00055g/unau th
the synthesis of Sceletium alkaloids mesembrine … Sceletium alkaloids were constructed
in high yields. The strategic efficacy was further validated in the synthesis of several Sceletium
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how it feels to be american in 2026
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The dianion formed by reduction of (η6:η6-4,4′-dimethoxybiphenyl)[Cr(CO)3]2 reacts with electrophiles such as methyl or ethyl triflate or allyl tosylate at −78 °C followed by CF3CO2H and I2 to form 4-alkyl-4-(4-methoxyphenyl)cyclohex -2-en-1-ones.
Graphic
https://ars.els-cdn.com/content/image/1-s2.0-S0040403900807923-gr1.gif
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>>220809844
So embarrassed over this Trump shit, him being a compromised pedo faggot of Israel and speedrunning his chore list of things to do for the Mossad. Nazi Germany only invaded Czechoslovakia and Poland, but we've invaded the entire world for globoshlomo.